Capillary morphogenesis protein 2
WebMar 21, 2024 · IFT74 (Intraflagellar Transport 74) is a Protein Coding gene. Diseases associated with IFT74 include Joubert Syndrome 40 and Spermatogenic Failure 58.Among its related pathways are Organelle biogenesis and maintenance and Bardet-Biedl syndrome.Gene Ontology (GO) annotations related to this gene include chromatin … WebThis condition is due to mutations in the anthrax toxin receptor-2 ( ANTXR2) gene. This gene is also known as capillary morphogenesis protein-2. This gene is located on the long arm of chromosome 4 (4q21.21). Management [ edit] There is no presently known curative treatment for this condition. [citation needed] Management is supportive
Capillary morphogenesis protein 2
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WebDec 27, 2012 · DOI: 10.3390/toxins5010001. Abstract. Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax … WebJul 28, 2009 · Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Proc Natl Acad Sci U S A. 2009 Jul 28;106 (30):12424-9. doi: …
WebMar 20, 2024 · HFS is a rare autosomal recessive disease without ethnic predilection caused by loss-of-function mutations in anthrax toxin receptor 2 gene (ANTXR2) (MIM #608041), also called capillary morphogenesis gene 2 (CMG2) at 4q21 (Dowling et al., 2003). It is expressed in all tissues except the brain and encodes a 55 kDa type I … WebMar 21, 2024 · intraflagellar transport protein 74 homolog, capillary morphogenesis gene 1 protein, capillary morphogenesis protein 1, coiled-coil domain containing 2, coiled-coil domain-containing protein 2, intraflagellar transport 74 homolog. GeneRIFs: Gene References Into Functions.
WebJun 27, 2024 · It is hypothesized that disruption of this membrane protein causes accumulation of hyaline materials and tissue damage/malfunction in multiple organs. 7 Owing to its rarity and associated rapid clinical deterioration, timely diagnosis of ISH is difficult and, as a result, it may be underdiagnosed.
WebJan 4, 2012 · Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 largely stems from the fact that it is involved in two diseases, one infectious and one ...
WebHere, we established mice with CMG2 only expressed in tumor endothelial cells (ECs) and determined the specific contribution of tumor stromal ECs to the toxin’s antitumor activity. Our results demonstrate that disruption of ERK signaling only within tumor ECs is sufficient to halt tumor growth. edward anania attorneyWebJan 3, 2024 · Since this activity requires the surface expression of the capillary morphogenesis protein-2 (CMG2) toxin receptor, genetic manipulation of CMG2 … edwarda munchaWebTwo distinct cellular receptors for anthrax toxin have been identified and are designated capillary morphogenesis protein 2 (CMG2) and anthrax toxin receptor/tumor endothelial marker 8 (ATR/TEM8). The molecular details of the toxin-receptor interactions have been revealed through crystallographic, biochemical and genetic studies. edward and bella bed sceneWebidentify the human capillary morphogenesis protein 2 (CMG2) as a second anthrax toxin receptor. CMG2 is the protein most similar to ATR TEM8 that has been described to … consultation boothWebCapillary morphogenesis gene 2 (CMG2) is a type I mem-brane protein involved in the homeostasis of the extra- ... cleaved by the pro-protein convertase furin into a 63-kDa protein. PA63 has the capacity to oligomerize into heptameric or octameric rings, to which EF/LF can bind. The binding to edward and amaury solicitorsWebApr 4, 2014 · Capillary morphogenesis gene 2 (CMG2), also known as anthrax toxin receptor 2, has been indicated in the formation of new vasculature and in the … consultation boite mail orangeWebCapillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Shihui Liu1, Devorah Crown, Sharmina Miller-Randolph, Mahtab Moayeri, … edward and bella anime