WebApr 8, 2024 · Endophytic fungi are a treasure trove of natural products with great chemical diversity that is largely unexploited. As an alternative to the traditional bioactivity-guided screening approach, the genome-mining-based approach provides a new methodology for obtaining novel natural products from endophytes. In our study, the whole genome of an … WebJan 11, 2024 · Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces …
Investigating the Function of Cryptic Cytochalasan Cytochrome …
WebCentre for Infection Research (HZI), Saarland University, Microbiology and Molecular Biology. Projects: Genome Mining of Natural Prodcuts from (Myxo)bacteria and Biosynthesis Study of. Intriguing Natural Products from rare Actinomyces strain. Sep 2024 - Jun 2024: State Key Laboratory of Microbial Technology, Shandong University, … WebA workflow of NMR-based metabolomics and bioinformatics was utilized for the identification of novel pyranonaphtoquinones. The constitutive expression of the pathway-specific activator, qin in Streptomyces sp. MBT76 resulted in the activation of the biosynthesis of a cryptic type II PKS compound belonging to the family of pyranonaphtoquinones ... flowsafe houston
A biosynthetic pathway to aromatic amines that uses …
WebFeb 4, 2024 · Two cryptic self-resistance mechanisms involving C-5 phosphorylation and N-7′ acetylation were discovered in Streptomyces tenebrarius to avoid auto-toxicity during apramycin biosynthesis. … WebJul 21, 2024 · In this study, we developed a novel approach to awake cryptic/silenced microbial biosynthetic pathways through augmentation of the conserved protein modification step-phosphopantetheinylation of carrier proteins. Overexpression of phosphopantetheinyl transferase (Pptase) genes into 33 Actinomycetes achieved a significantly high activation … WebNov 12, 2012 · Biosynthetic secrets unveiled: Targeted promoter exchange in a cryptic biosynthesis gene cluster conserved among certain pathogenic Burkholderia species yielded a highly unstable, structurally ... flowsafe sizing