WebDanon disease, primary lysosome-associated membrane protein-2 (LAMP-2) deficiency, is characterized clinically by cardiomyopathy, myopathy and intellectual disability in boys. ... which has been suggested to be caused by a 50% reduction in LAMP-2 expression (LAMP-2 haploinsufficiency) in female patients with Danon disease caused by a ... WebImpact. As part of Danone Renew strategy, the company reframed its sustainability journey, articulated around 3 pillars: Health, Nature and People & Communities . For each pillar, Danone defines a new set of priorities which are translated into mid to long-term objectives, focusing on where the company can deliver the most impact and value.
Danon disease: focusing on heart Journal of Human …
WebUsing the sulfhydryl antioxidant N-acetylcysteine to scavenge free radicals resulted in a significant reduction in apoptotic cell death in Danon iPSC-CMs. In summary, we have modeled Danon disease using human iPSC-CMs from patients with mutations in LAMP-2, allowing us to gain mechanistic insight into the pathogenesis of this disease. WebJan 8, 2024 · Danon disease is a rare X-linked dominant genetic disorder that manifests … chippewa pull on boots 20077
Danon Disease Treatment & Management - Medscape
WebMar 16, 2011 · Abstract. Background: Danon disease is a rare but serious cardiac and skeletal myopathy leading to substantial morbidity and early mortality due to arrhythmia and cardiomyopathy. The X-linked ... WebOct 24, 2009 · Mathematical models, and the statistical tools that underpin them, are now a fundamental element in planning control and mitigation measures against any future epidemic of an infectious disease. Well-parameterized mathematical models allow us to test a variety of possible control strategies in computer simulations before applying them … grapefruit seed extract fresh thyme