Phospholipase a2 gene

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August undefined, 2024

WebThis gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. WebMar 17, 2024 · The PLA2G6 gene encodes a group of VIA calcium-independent phospholipase A2 (iPLA2β) enzymes, which participate in various cellular functions, including phospholipid metabolism, membrane homeostasis, calcium signaling, apoptosis, and mitochondrial function. Thus, these functions could be perturbed by PLA2G6 gene …

Phospholipase A2 - an overview ScienceDirect Topics

WebPhospholipases are lipolytic enzymes that hydrolyze phospholipid substrates at specific ester bonds. Phospholipases are widespread in nature and play very diverse roles from aggression in snake venom to signal transduction, lipid mediator production, and metabolite digestion in humans. Phospholipase … WebFeb 17, 2024 · The phospholipase A2 (PLA2) gene encodes the enzyme that catalyzes the hydrolysis of phospholipids (PLs) from the sn-2 position. However, little is known about its role in humoral immune responses. onyx boox charger

Host phospholipid peroxidation fuels ExoU-dependent cell …

WebSpecifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels of a compound called phosphatidylcholine, which is … WebCalf skeletal muscle gene expression of patients with PAD and healthy subjects was analyzed using microarrays. The top-ranking gene differentially expressed between PAD and controls (FDR < 0.001) was PLA2G16 , which encodes adipose-specific phospholipase A2 (AdPLA) and is implicated in the maintenance of insulin sensitivity and regulation of ... WebDec 1, 2024 · Phospholipase is an enzyme that hydrolyzes ester bonds of glycerophospholipids; of these, phospholipases involved in the release of fatty acids are classified as phospholipase A (PLA). Furthermore, PLA is categorized into PLA1 and PLA2. onyx boox assistant

Identification and expression of phospholipase A2 genes related …

OMIM Entry - * 603604 - PHOSPHOLIPASE A2, GROUP VI; PLA2G6

WebSullivan CP, Seidl SE, Rich CB et al Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem 285:565–575 WebAug 7, 2024 · PheneGene Graphics TEXT Description Phospholipase A2-activating protein (PLAA, or PLAP) is potentially important in regulating the inflammatory response through its activation of phospholipase A2 (e.g., 600522 ), which catalyzes the release of arachidonic acid ( Chopra et al., 1999 ). onyx book air 2WebJan 5, 2024 · ATSPLA2-ALPHA; PHOSPHOLIPASE A2-ALPHA Summary Encodes a secretory phospholipase A2 enzyme, which specifically hydrolyzes the sn-2 position of … iowa alzheimer\\u0027s association

"WebMar 28, 2024 · PLA2B, the synovial phospholipase A2 described by Seilhamer et al. (1989), is a small molecular weight enzyme that is DTT-sensitive. PLA2B is secreted from cells, active in the micromolar to millimolar calcium concentration range that prevails in the extracellular medium, and active in inflammatory exudates. " - Phospholipase a2 gene

Phospholipase a2 gene

WebPhospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins (PGs) and leukotrienes (LTs). The same reaction also produces lysophosholipids, which represent another class of lipid mediators.

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WebHas phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid ( By similarity ). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion ( By similarity ). WebApr 3, 2024 · Phospholipase A2 Group IIa may be a modifier gene for fundic gland polyposis in patients with familial adenomatous polyposis PLA2G2A haplotypic variation strongly …

WebPHOSPHOLIPASE A2 (PLA2) ENZYME PREPARATION FROM STREPTOMYCES VIOLACEORUBER EXPRESSING A GENE ENCODING PLA2 FROM S. VIOLACEORUBER … WebMar 8, 2024 · The sequences of mammalian phospholipases were collected in the database UniProt by entering the gene names PLA2G1B and PLA2G2A, considering only the ten curated entries for PLA2G1B, and the five curated entries plus five other entries in the case of PLA2G2A. ... The phospholipase A2 superfamily and its group numbering system. …

WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic phospholipase A2 … WebPhospholipase A2: hydrolyzes the glycerol-fatty acid ester in position 2. ... This gene encodes a phospholipase A 2 enzyme that plays a crucial role in mitochondrial membrane …

The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule: phosphatidylcholine + H2O = 1 … See more Phospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. Other families include Ca independent … See more The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. The … See more Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. cPLA2 is regulated by phosphorylation and calcium concentrations. … See more Human phospholipase A2 isozymes include: • Group I: PLA2G1B • Group II: PLA2G2A, PLA2G2C See more PLA2 action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils. See more In normal brain cells, PLA2 regulation accounts for a balance between arachidonic acid's conversion into proinflammatory mediators and its reincorporation into the membrane. In the absence of strict regulation of PLA2 activity, a … See more • Paul Sigler See more

WebPLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). iowa american firefighting equipmentWebNational Center for Biotechnology Information onyx boox battery lifeWebBackground Ureases are multifunctional enzymes that display biological activities independent of their enzymatic function, including exocytosis induction and insecticidal effects. The hemipteran Rhod onyx boox cloud loginWebPLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating … onyx boox discount codeWebMar 28, 2024 · In a Serbian brother and sister with GURDP, Brooke et al. (2014) identified a homozygous 4-bp deletion in the PLA2G4A gene ( 600522.0004 ). The mutation, which … onyx boox dictionaryWebPLA2G2A (human) Gene Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National … iowa alternative teaching licenseWebENCODES a protein that exhibits calcium-independent phospholipase A2 activity (ortholog); lysophospholipase activity (ortholog); O-acyltransferase activity (ortholog); INVOLVED IN glycerophospholipid catabolic process (ortholog); lipid droplet formation (ortholog); phosphatidylcholine acyl-chain remodeling (ortholog); ASSOCIATED WITH genetic disease … onyx boox dictionary download